CGRPR/CRE Luciferase Reporter HEK293 Cell Line

●Purchase●DescriptionRecombinantHEK293celllinestablyexpressingfull-lengthhumancalcitoninreceptor-likereceptor(CALCRL/CRLR/CLR

产品型号：78325
厂商性质：生产厂家
更新时间：2023-11-11
访问量：274

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Description

Recombinant HEK293 cell line stably expressing full-length human calcitonin receptor-like receptor (CALCRL/CRLR/CLR; accession number: NM_005795) and firefly luciferase under the control of a multimerized cAMP response element (CRE). This cell line can be used to measure the EC₅₀ and IC₅₀ of CGRP receptor agonists and antagonists using luciferase reporter activity as read-out.

Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.

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Synonyms

Calcitonin gene-related peptide type 1 receptor, CGRP type 1 receptor, Calcitonin receptor-like receptor, CRLR, CGRPR, LMPHM8, CALCRL, CLR

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Product Data Gallery

Cell surface expression of human CALCRL in CGRPR/CRE Luciferase Reporter HEK293 Cell Line.

Dose response of CGRPR/CRE Luciferase Reporter HEK293 Cell Line to the agonists α-CGRP and β-CGRP.

Dose response of CGRPR/CRE Luciferase Reporter HEK293 Cell Line to the small molecule antagonist Rimegepant.

Dose response of CGRPR/CRE Luciferase Reporter HEK293 Cell Line to the anti-CGRP Eptinezumab.

Dose response of CGRPR/CRE Luciferase Reporter HEK293 Cell Line to the anti-CGRP antibody Galcanezumab.

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CGRPR/CRE Luciferase Reporter HEK293 Cell Line

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