STAT3 Luciferase Reporter HEK293 Cell Line

●Purchase●DescriptionTheSTAT3LuciferaseReporterHEK293CellLineisaHEK293celllinesexpressingfireflyluciferasedrivenbySTAT3responseelementslocatedupstreamofaminimalTATApromoter

产品型号：79800-P
厂商性质：生产厂家
更新时间：2023-11-11
访问量：185

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Description

The STAT3 Luciferase Reporter HEK293 Cell Line is a HEK293 cell lines expressing firefly luciferase driven by STAT3 response elements located upstream of a minimal TATA promoter. After activation by cytokines or growth factors, endogenous STAT3 binds to the response elements, inducing transcription of the luciferase reporter.

This cell line has been validated to respond to human interleukin-6 (IL-6) and human IL-27. Functional validation experiments showed that IL-6-induced luciferase activity was decreased by the JAK inhibitor CP 690,550 and by an anti-IL-6 Receptor neutralizing antibody.

Figure 1: Illustration of the mechanism behind reporter expression in the STAT3 Luciferase Reporter HEK293 Cell Line.
Created with BioRender.com

This product has been cited 1 time.

Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.

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Synonyms

Acute-Phase Response Factor, DNA-Binding Protein APRF, ADMIO, Signal Transducer And Activator Of Transcription 3

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Product Data Gallery

Dose response curve of STAT3 Luciferase Reporter HEK293 Cell Line to hIL-6

Dose response curve of STAT3 Luciferase Reporter HEK293 Cell Line to hIL-27

Inhibition of hIL-6-induced reporter activity by JAK Inhibitor CP 690,550 in STAT3 Luciferase Reporter HEK293 Cell Line.

Inhibition of hIL-6-induced reporter activity by anti-IL-6R antibody in STAT3 Luciferase Reporter HEK293 Cell Line

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STAT3 Luciferase Reporter HEK293 Cell Line

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