ADCC Bioassay Effector Cell (Mouse) Jurkat Cell Line

The ADCC Bioassay Effector Cell (Mouse) Jurkat Cell Line (mFcγRIV /NFAT-Jurkat cells) are engineered Jurkat cells that express firefly luciferase, under the control of NFAT response elements, and mouse FcγRIV (NM_144559.2). This cell line was functionally validated in an ADCC (antibody-dependent cell-mediated cytotoxicity) assay.

Figure 1: Illustration of the mechanism of action of ADCC Bioassay Effector Cell (Mouse) Jurkat Cell Line. ADCC Bioassay Effector Cell (Mouse) Jurkat cells are used as effector cells. The Fc effector portion of antibodies binds to target antigens on the target cell surface and also binds to mFcγRIV on the cell surface of effector cells, cross-linking of the effectors and target cells. Binding to mFcγRIV leads to the activation of NFAT pathway in the effector cells. Luciferase activity is proportional to the amount of crosslinking and activation of the ADCC cascade.

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