AR-42 (OSU-HDAC42)

●Purchase●DescriptionAR-42(alsoknownasOSU-HDAC42),aderivativeofhydroxamate-tetheredphenylbutyrateisabroad-spectrumdeacetylaseinhibitorofbothhistoneandnon-histoneproteins

产品型号：27603-3
厂商性质：生产厂家
更新时间：2023-11-11
访问量：112

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Description

AR-42 (also known as OSU-HDAC42), a derivative of hydroxamate-tethered phenylbutyrate is a broad-spectrum deacetylase inhibitor of both histone and non-histone proteins. AR-42 treatment induces histone hyperacetylation and p21WAF/CIP1 overexpression, inhibits gp130/Stat3 pathway and induces apoptosis and cell cycle arrest in multiple myeloma cells.

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Synonyms

OSU-HDAC42; N-hydroxy-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamide

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AR-42 (OSU-HDAC42)

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