EPZ015666

●Purchase●DescriptionEPZ015666isapotent,selective,competitivePRMT5inhibitor(IC50=22nM)

产品型号：79043-2
厂商性质：生产厂家
更新时间：2023-11-11
访问量：103

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Description

EPZ015666 is a potent, selective, competitive PRMT5 inhibitor (IC50 = 22 nM). EPZ015666 exhibits >10,000-fold specificity for PRMT5 vs. other methyltransferases. EPZ015666 blocks the association of PRMT5 with methylosome protein 50 (WDR77), which is necessary to form an active methyltransferase complex. Treatment of MCL cell lines with nM concentrations of EPZ015666 leads to inhibition of SmD3 methylation and cell death."

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Synonyms

PRMT5, HRMT1L5, IBP72, JBP1, SKB1, PRMT Protein

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EPZ015666

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