SP600125

●Purchase●DescriptionNovel,potentandselectiveJNK-1,-2,and-3inhibitor(Ki=0

产品型号：27023
厂商性质：生产厂家
更新时间：2023-12-19
访问量：105

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Description

Novel, potent and selective JNK-1,-2, and -3 inhibitor (Ki = 0.19 µM). SP600125 is an ATP-competitive reversible inhibitor with >20-fold selectivity vs. a range of kinases and enzymes tested. In cells, SP600125 caused a dose-dependent inhibition of the phosphorylation of c-Jun, the expression of inflammatory genes IL-2, COX-2, TNF-α, IFN-γ, and blocked the activation and differentiation of primary human CD4 cell cultures.

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Synonyms

Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone, Anthrapyrazolone, JNK Inhibitor II

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SP600125

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