PRODUCT CLASSIFICATION

产品分类

细胞库 / 细胞培养

TECHNICAL ARTICLES

相关文章

OPUS娱乐平台 / Product display

您的位置：首页 / OPUS娱乐平台 / / 细胞库 / 细胞培养 / IRF Reporter (Luc) - THP-1 Cell line (cGAS-Sting Signaling Pathway)

IRF Reporter (Luc) - THP-1 Cell line (cGAS-Sting Signaling Pathway)

产品型号：
厂商性质：生产厂家
更新时间：2023-10-12
访问量：221

立即咨询

联系电话：

详细介绍

数量：
1
供应商：
BPS Bioscience
细胞类型：
稳转细胞系
品系：
THP-1
组织来源：
/
相关疾病：
多种
物种来源：
human
免疫类型：
多种
器官来源：
无
运输方式：
干冰
年限：
10
生长状态：
良好
CAS号：
无
英文名：
IRF Reporter (Luc) - THP-1 Cell line (cGAS-Sting Signaling Pathway)
注册证号：
/
规格：
2管

The Interferon Regulatory Factor (IRF) reporter (Luc)-THP-1 cell line is designed to study the activation and signaling of Cytosolic DNA Sensors (CDS) in human monocytic cell line THP-1. It contains a firefly luciferase gene driven by multimerized ISRE (Interferon Stimulated Response Element) located upstream of the minimal TATA promoter. The cGAS-STING pathway acts to detect cytosolic DNA and induce an immune response. Briefly, upon binding DNA, the protein cGAS (cyclic GMP-AMP Synthase) triggers reaction of GTP and ATP to form cGAMP. cGAMP binds to STING (Stimulator of Interferon Genes) which triggers phosphorylation of IRF3 via TBK1. IRF3 can then bind to interferon-stimulated responsive elements (ISRE) in the nucleus and leads to IFN-α/β production. The IRF reporter (Luc)-THP-1 cell line is highly responsive to STING and CDS ligands.

留言询价

IRF Reporter (Luc) - THP-1 Cell line (cGAS-Sting Signaling Pathway)

留言框

产品：

您的单位：

您的姓名：

联系电话：

常用邮箱：

省份：

详细地址：

补充说明：

验证码：