ND-630

保存条件：roomtemp

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厂商性质：生产厂家
更新时间：2023-12-19
访问量：208

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详细介绍

保存条件：
room temp.
保质期：
Store at -20°C for up to a year. Dissolve in anhydrous DMSO and store DMSO stock solutions at 4°C for a couple of days or store stock solutions at -20°C in aliquots for up to a month. Avoid freeze/thaw cycles of solutions.
英文名：
ND-630
数量：
1
供应商：
BPS Bioscience Inc.
CAS号：
/
规格：
1 mg

ND-630 (NDI 010976) is a highly specific, reversible inhibitor of ACC1 (IC50 = 2 nM) and ACC2 (IC50 = 6 nM). ND-630 interacts within the ACC phosphopeptide acceptor and dimerization site to prevent dimerization of ACC. Because the dimerization site is not conserved among other mammalian carboxylases, ND-630 lacks the ability to inhibit other mechanistically-related enzymes. In rats with diet-induced obesity, ND-630 reduced hepatic steatosis, improved insulin sensitivity, and reduced weight gain, suggesting ACC inhibition may be useful in treating metabolic disorders, including type 2 diabetes mellitus, and fatty liver disease.

温馨提示：不可用于临床治疗。

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ND-630

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