NVP-BEP800

保存条件：Roomtemp

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厂商性质：生产厂家
更新时间：2023-12-19
访问量：180

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详细介绍

保存条件：
Room temp. (continental US) or gel packs
保质期：
Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
英文名：
NVP-BEP800
数量：
1
供应商：
BPS Bioscience Inc.
CAS号：
/
规格：
10 mg

NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor that binds to the NH(2)-terminal ATP-binding pocket of Hsp90. NVP-BEP800 (also known as VER-82576) is a novel ATP-competitive HSP90β inhibitor that binds to the NH(2)-terminal ATP-binding pocket of Heat shock protein 90 (Hsp90). NVP-BEP800 induced robust antitumor responses in tumor xenograft models, including regression in the BT-474 breast cancer model. NVP-BEP800 can radiosensitise tumour cell lines of different entities through destabilisation and depletion of several Hsp90 client proteins, thus causing the depletion of S phase and G2/M arrest, increased DNA damage and repair protraction and, to some extent, apoptosis.

温馨提示：不可用于临床治疗。

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NVP-BEP800

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